Torneranno Margot Robbie come Harley Quinn, Viola Davis nel ruolo Amanda Waller, Joel Kinnaman in quelli di Rick Flag e Jai Courtney in quelli di Captain Boomerang.
James Gunn è stato chiamato a dirigere la nuova avventura.
Questi invece sono i nuovi entrati:
- Michael Rooker as Savant
- Flula Borg as Javelin
- David Dastmalchian as Polka-Dot Man
- Daniela Melchior as Ratcatcher 2 (the two is very important)
- Idris Elba as Bloodsport
- Steve Agee as the voice of King Shark
- Mayling Ng as Mongal
- Peter Capaldi as Thinker
- Alice Braga as Solsoria
- Pete Davidson as Blackguard
- Nathan Fillion as TDK
- Sean Gunn as Weasel
- John Cena as Peacemaker